In 1978 at the age of 23, Mike MacDonald began to frequent clubs where he could try his own brand of stand-up comedy. As Mike MacDonald’s reputation grew, so did the job offers. Mike MacDonald quit his day job in order to make his sole living from comedy.

Mike MacDonald began to perform throughout Canada and made frequent forays into the United States. In addition to his successful and well received live performances all over North America, Mike MacDonald has appeared on numerous TV shows including "Late Night With David Letterman" and "The Arsenio Hall Show".

Mike MacDonald has been nominated for two Gemini Awards and two Ace Awards for his comedy writing and performances.

In the 1990s, he starred in three Showtime and CBS specials, “Mike MacDonald On Target”, “My House My Rules”, and “Happy As I Can Be”. Still more recently, he hosted his own CBC special, “Mike MacDonald’s Politically Correct Christmas Special”, and starred in “The Rogers Cable”, a 10-minute short that appeared at the Cannes Film Festival.

Mike continues to tour across Canada and the U.S., and is currently working on a variety of feature film projects.