Brian Regan's done stand-up around a dozen times on The Late Show with David Letterman, which is more than any other comic has been on Letterman's CBS show. Regan has also been on Conan and Leno. Regan has opened for Seinfeld and has a DVD of his stand-up named I Walked on the Moon. Mitch Fatel, another comic, said that Brian Regan, Seinfeld, and Ray Romano are the only three people who have ever made him cry from laughing so hard.
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