Space Ghost was one half of the animated television series Space Ghost and Dino Boy created by Hanna-Barbera Productions; it first aired on September 10, 1966 on CBS.

In the series, the hero, Space Ghost, battled villains in outer space. Space Ghost was assisted by two teenagers named Jan (voiced by Ginny Tyler) and Jace (voiced by Tim Matheson), and a monkey named Blip (voiced by Don Messick). The show ended on September 7, 1968.

The character of Space Ghost was revived for a series in 1994 on Cartoon Network. Villains Zorak (a giant praying mantis) and Moltar were Space Ghost's sidekicks (with guest apparances from many other old SG villains, most notably Brak) as he led a talk show in the style of late-night shows such as David Letterman called Space Ghost: Coast to Coast, as well as the short-lived Cartoon Planet.

Celebrities interviewed by Space Ghost included Beck, Bobcat Goldthwait, and The Ramones. It was a very odd show, and often slipped into the absurd.

The strange humor, the renovated characters, and many unknown elements combined to make viewing a surreal experience. SGC2C continues to this day as the elder program on CN's late-night comedy/action programming block, Adult Swim.

On the old show, Space Ghost was voiced by Gary Owens. On the new show Space Ghost is voiced by George Low.